The Most Up-To-Date Medicare-Approved Amniotic Membrane Allografts

Medicare coverage for amniotic membrane allografts changes every quarter.
Q-codes are added, removed, repriced, and subject to updated MUE limits—making it increasingly difficult for wound-care providers to stay compliant while optimizing outcomes and reimbursement.

This quarterly comparison guide from KOSMD Consulting provides a single, authoritative reference for Medicare-approved amniotic membrane and placental tissue allografts currently assigned Q-codes. It is designed for physicians, wound centers, and healthcare organizations that need accurate, current, and actionable information—not outdated lists or manufacturer marketing. This quarterly comparison guide from KOSMD Consulting provides a single, authoritative reference for Medicare-approved amniotic membrane and placental tissue allograft.

This guide is updated every quarter to reflect CMS and MAC policy changes and is used by clinicians to support compliant product selection, documentation, and ordering decisions across advanced wound-care programs.

Selecting an amniotic membrane or skin substitute based on outdated coverage information can result in denials, clawbacks, and compliance risk—even when clinical outcomes are excellent.

Medicare assigns, revises, or retires Q-codes and adjusts ASP and MUE limits on a quarterly basis, often with little notice. This guide consolidates those updates into a single clinical and operational reference, helping providers align product selection with MAC and payer expectations through a secure amniotic membrane ordering portal:

• Identify which amniotic membrane allografts are currently Medicare-assigned
• Understand applicable Q-codes, ASP pricing, and MUE thresholds
• Align product selection with MAC and payer expectations
• Reduce billing risk while optimizing advanced wound-care outcomes

• Always the Most Current Medicare-Approved List
• Same-Day Ordering with no backorders.
• Real-Time Inventory
• HIPAA-Compliant Platform
• Competitive pricing and bulk order options
• Optional discounted AI billing with 98% first-pass claims paid
• Optional “Claw-back” protection

• Educational overview of the current Q3 2025 Medicare-assigned allograft list
• Clinical context for compliant amniotic membrane selection

Verified providers can access the full, always-current list through a physician-only amniotic membrane portal—including quarterly ASP and MUE updates, pricing, ordering tools, and compliance workflows—through the KOSMD Consulting secure portal.

1️⃣ Xcell Amnio Matrix (Q4280)

Excellent for: Acute and chronic wounds including DFUs, VLUs, pressure injuries, MOHS defects, and large acute wounds.

• Type: Single-layer lyophilized amniotic membrane
• Strengths: Shelf-stable,Easy handling, consistent application

2️⃣ Activate Matrix (Q4301)

Excellent for: DFUs, VLUs, pressure/sacral wounds, MOHS, large acute wounds

• Type: Three-layer (amnion + chorion + intermediate layer)
• Strengths:

3️⃣ MW Hydro (Q4290)

Excellent for: chronic & acute wounds

• Type: dHAM Membrane wrap,
• Strengths: minimally manipulated, easy to mold for tunneled wounds

4️⃣ Membrane Wrap (Q4205)

Excellent for: Acute wounds, smaller ulcers, acute traumatic wounds & lacerations

• Type: Single-layer amnion-amnion tissue
• Strengths: Conforms easily

5️⃣ AmnioAmp-MP (Q4250)

Excellent for: Acute & Chronic wounds: DFU’s, VLU’s, Pressure/Sacral, Burn, Partial & full thickness wounds, Exposed tendons, muscle & bone, arterial insufficiency wounds, acute traumatic wounds & lacerations

• Type: Dual-layer
• Strengths: PūrAMP Process™
• E-Beam sterilization
• 1 yr Shelf life

6️⃣ Esano ACA (Q4275)

Excellent for: acute & Chronic wounds, DFUs, VLUs, Pressure Sacral, burn, vascular wounds, acute traumatic wounds & lacerations

• Type: Four-layer novel allograft
• Strengths:
• Terminally Sterilized
• Non-side specific
• Thickness & enhanced tensile strength= easy handling
• No need to hydrate
• 5 yr Shelf life

7️⃣ Simplimax (Q4341)

Excellent for: acute & Chronic wounds, DFUs, VLUs, Pressure Sacral, burn, vascular wounds, acute traumatic wounds & lacerations

• Type: Dual Layer
• Strengths:
• Non-side specific
• Enhanced tensile strength & thickness = easy handling
• No need to hydrate
• 5 yr Shelf life

8️⃣ Amchoplast (Q4316)

Excellent for: acute & Chronic wounds, DFU’s, burns, pressure sores, nerve & tendon repair, surgical reconstruction, acute traumatic wounds & lacerations’

• Type: dHCAM Dual-layer (amnion + chorion)
• Strengths:
• Terminally sterilized
• Structural integrity: scaffold & barrier
• 3 yr Shelf life

9️⃣ Tri Membrane Wrap (Q4344)

Excellent for: acute & Chronic wounds, DFU’s, burns, pressure sores, nerve & tendon repair, surgical reconstruction, acute traumatic wounds & lacerations

• Type: Triple-layer dHCAM allograft
• Strengths:
  • Terminally sterilized
  • Increased thickness, tensile strength
  • Works with wound VAC systems
  • Shelf life extended